HMGCR antibodies Indication Suspicion of immune-mediated necrotizing myopathy (IMNM). Anti-HMCGR is strongly associated with previous statin therapy. Method Quanta Lite HMGCR ELISA. Response The test result is given as negative or positive with a value. Reference value: Negative <20 U/mL, Positive ≥20 U/ mL.

Necrotizing autoimmune myopathy (NAM) is a serious but rare muscle disease strongly associated with autoantibodies to either signal recognition protein (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).

Format: Liquid. Concentration: 1mg/ml. Storage Condition and Buffer: HMGCR Antibodies Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. HMGCR Autoantibodies.

Western blot - Anti-HMGCR antibody [CL0260] (ab242315) All lanes : Anti-HMGCR antibody [CL0260] (ab242315) at 1 µg/ml. Lane 1 : MCF7 (human breast adenocarcinoma cell line) whole cell lysate. 2020-08-13 · HMGCR Abs (3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase) are associated with necrotizing myopathy that is commonly related to statin exposure. Limitations This test was developed and its performance characteristics determined by LabCorp.

Nov 25, 2019 a diagnostic alert that anti-HMGCR related immune mediated necrotizing myopathy should (HMGCR) antibody, which was strongly positive.

Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Anti-HMGCR myopathy was first recognized and characterized in patients with a history of statin exposure and immune-mediated necrotizing myopathy. After the discovery of anti-HMGCR autoantibodies, several international groups identified and characterized more patients, expanding the phenotypic spect … Recently, auto-antibodies (AAbs) to the enzyme, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was shown to be a MSA that was strongly associated with immune mediated necrotising myopathy (Arthritis Rheum. 2010 Sep;62(9):2757-66.

Immunofluorescence analysis of A-549 cells using HMGCR antibody (STJ115278). Blue: DAPI for nuclear staining. Western blot analysis of extracts of various cell lines, using HMGCR antibody (STJ115278) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

Independently reviewed in 1 review(s). Immunogen … IgG antibodies to HMGCR in the setting of muscle weakness and a raised CK are highly suggestive of an autoimmune necrotising myositis. Many cases are associated with statin exposure although this is not universal. In those with statin exposure the myositis does not resolve with drug cessation. HMGCR Antibody: Chronic Myopathy, Young onset.

免疫原: A synthesized peptide derived from human HMGCR, corresponding to a region within N-terminal amino acids. RRID: AB_2838480 引用格式: Affinity Biosciences Cat# DF6518, RRID:AB_2838480. 形式: Liquid. 浓度: 1mg/ml.
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HMGCR antibody Rabbit Polyclonal from Proteintech validated in Immunohistochemistry (IHC), Immunofluorescence (IF),Enzyme-linked Immunosorbent Assay (ELISA) applications. This antibody reacts with human, mouse, rat samples. HMGCR antibody–associated myopathies can be considered in the context of the common clinical classification and our proposed pathologic groups of immune myopathies. 3 Polymyositis and inclusion body myositis can be ruled out because there are few lymphocytic inflammatory foci or inclusion bodies in HMGCR myopathies. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.

HMGCR Antibodies Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Anti-HMGCR myopathy was first recognized and characterized in patients with a history of statin exposure and immune-mediated necrotizing myopathy.
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Anti-HMGCR myopathy was first recognized and characterized in patients with a history of statin exposure and immune-mediated necrotizing myopathy. After the discovery of anti-HMGCR autoantibodies, several international groups identified and characterized more patients, expanding the phenotypic spect …

HMGCR has a mass of 97.48kDa and an amino acid length of 888. We offer 9 antibodies to HMGCR, raised in Rabbit, which are suitable for Western Blot, IHC, ELISA and ICC/IF with samples derived from Human, Mouse and Rat. HMGCR Antibody detects endogenous levels of total HMGCR. 免疫原: A synthesized peptide derived from human HMGCR, corresponding to a region within N-terminal amino acids.